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肿瘤微环境在肝细胞癌中的研究进展

Research progress of tumor microenvironment in hepatocelluar carcinoma

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【作者】 权虎石磊陈杰罗嘉陈攀谢威

【Author】 QUAN Hu;SHI Lei;CHEN Jie;LUO Jia;CHEN Pan;XIE Wei;Department of Hepatobiliary Enterosurgery, Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South Univerisity;Animal Laboratory Center, Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South Univerisity;

【通讯作者】 谢威;

【机构】 湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院肝胆肠外科湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院动物实验中心

【摘要】 肝癌是世界上常见的恶性肿瘤,早期肝癌症状无特异性。越来越多的研究表明,肿瘤微环境是导致肝脏细胞发生恶性转变的重要原因之一。有大量研究报道了肝癌微环境的作用,本文主要从肝癌肿瘤微环境的主要组成、肿瘤微环境在肝癌中的作用以及针对肝癌微环境的靶向治疗等几个方面进行总结,以期有助于改善肝癌的诊断、治疗和预后,提高肝癌患者的生存率。

【Abstract】 Liver cancer is a common malignant tumor in the world. The liver cancer in early stage had no specific symptoms. More and more studies have shown that tumor microenvironment(TME) is one important cause for malignant transformation of hepatocytes. Many studies have reported the role of TME in liver cancer. This article mainly summarized the compositions and the role of TME in liver cancer, as well as the targeting therapy for liver cancer microenvironment, so as to help improve the diagnosis, treatment and prognosis of liver cancer, and improve the survival rates of patients with liver cancer.

【关键词】 肝癌肿瘤微环境肿瘤基质
【Key words】 Liver cancerTumor microenvironmentTumor stroma
【基金】 湖南省自然科学基金(2019JJ40177,2020JJ4416);湖南省临床医疗技术创新引导项目(2020SK51108);湖南省卫生健康委科研计划项目(20200545);长沙市自然科学基金(kq2004135)
  • 【文献出处】 肿瘤药学 ,Anti-tumor Pharmacy , 编辑部邮箱 ,2023年02期
  • 【分类号】R735.7
  • 【下载频次】357
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