【摘要】 氧化应激涉及多种疾病的发生和发展以及人体的衰老过程。DJ-1/PARK7基因编码DJ-1蛋白,研究发现其具有多种生物学功能,包括细胞的恶性转化、雄性精子成熟与受精、促进细胞增殖及抵抗氧化应激等。近年来DJ-1抗氧化应激功能日益受到重视。研究层次包括体外实验、体内实验和临床研究。其机制主要包括自身构型改变、分子伴侣作用、保护线粒体功能、调控抗凋亡基因和抗氧化相关基因。对DJ-1进一步研究可能为氧化应激相关性疾病的预防和治疗提供新策略。更多还原

【Abstract】 Oxidative stress is implicated in the pathogenesis and progression of various diseases as well as in the natural aging process.DJ-1/PARK7 gene encodes DJ-1 protein,which participates in malignant transformation,sperm maturation and fertilization,cell proliferation promotion,and anti-oxidative stress.The anti-oxidative stress effect of DJ-1 has been drawing increasing attention in recent years.There have been related in vitro,in vivo and clinical studies.The main mechanisms of its anti-oxidation effects included modifying configuration,playing the role of molecular chaperones,protecting the mitochondrial function,and regulating anti-apoptosis genes and antioxidant-related genes.Further research on DJ-1 may provide a new strategy for the prevention and treatment of oxidative stress-related diseases.更多还原